1st appearance of Gwen Stacy's father George Stacy.
Spider-man gets struck by amnesia after being exposed to the Nullifier. Dr. Octopus then convinces him to commit crimes together, but Spider-man doesn't feel right. Dr. Octopus then tries to get Spider-man to reveal his true identity, and he realises at this point that if Dr. Octopus and him were partners, he would have already known his identity. Spider-man then battles Dr Octopus, and John Jameson manages to immobilise Dr Octopus.
Key ASM Silver Age issue independently assessed at Very Fine (8.0). Note that I'm a comic reader and collector, not a professional grader, these comics are assessed by 3rd parties. All comics come bagged and boarded.